反应详情

温度

0 °C

To a mixture of concentrated sulfuric acid (81 mL) and concentrated nitric acid (15.5 mL), cooled to 0° C., was added 2-trifluoromethoxybenzaldehyde (25 g, 0.13 mol) portionwise while maintaining the temperature of the reaction below 0° C. After 1.5 hours, the reaction mixture was poured cautiously over 1000 mL of ice in a large beaker and left to stand for 0.5 hours. The resulting suspension was filtered, washed well with H2O and air dried to give crude 5-nitro-2-trifluoromethoxybenzaldehyde, m.p. 32°-34° C.

1. temperaturewhile maintaining
2. customthe temperature of the reaction below 0° C
3. waitleft
4. waitto stand for 0.5 hours
5. filtrationThe resulting suspension was filtered
6. washwashed well with H2O and air
7. customdried