Benzyl Alcohol → 1-Benzoyl-5-methoxy-2-methylindole-3-acetic acid

Participants

Reaction Steps

A solution of 15 g. of methyl-(2-methyl-5-methoxy-3-indolyl) acetate and 0.2 g. of sodium in 60 ml. of benzyl alcohol is slowly fractionated over a period of 41/2 hours through a Vigreux column to remove methanol. The excess benzyl alcohol is then removed by distillation at 60° C. (2.5 mm.) to give a residue of 18.6 g. of benzyl-(2-methyl-5-methoxy-3-indolyl)-acetate.

Provenance & Evidence