Sodium Hydroxide → HCID 10016371, compound

Participants

Reaction Steps

A suspension of 3.06 g. (0.01 mole) of ethyl-5-(ρ-chlorobenzoyl)-1-methylpyrrole-2-acetate in 25 ml. of 0.5N sodium hydroxide is refluxed for 30 minutes. About two-thirds of this solution is cooled, washed with ether, and then acidified with dilute hydrochloric acid. The resulting solid precipitate is collected by filtration, dried and recrystallized from ethanol-water to give the product, 5-(ρ-chlorobenzoyl)-1-methylpyrrole-2-acetic acid; M.P. 189°-191° C. Upon recrystallization from ethanol-water, the melting point is 188°-190° C. The other one-third of the solution is cooled in an ice-bath whereupon the yellow sodium salt of the acid is precipitated and collected by filtration.

Provenance & Evidence