Ethanol → HCID 18424176, compound

HRID 863637Notes

Reaction equation

HRID 863637 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH:14]([CH3:20])[C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+].C(O)C>O>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH:14]([CH3:20])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 18424383HCID 18424383, compound

Product 1

HCID 18424176HCID 18424176, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4.05 g. (0.0126 mole) of ethyl 5-(ρ-chlorobenzoyl)-α-methyl-1-methylpyrrole-2-acetate, 15 ml. of 1N sodium hydroxide solution and 2 ml. of ethanol is refluxed for 30 minutes. The solution is cooled, diluted with water and filtered. The filtrate is acidified with dilute hydrochloric acid. The precipitates solid is collected and recrystallized from methanol-water to give a white crystalline solid, 5-(ρ-chlorobenzoyl)-α-methyl-1-methylpyrrole-2-acetic acid, M.P. 135°-136° C.

Workup

  1. temperatureThe solution is cooled
  2. filtrationfiltered
  3. customThe precipitates solid is collected
  4. customrecrystallized from methanol-water

Sources & evidence

ORD record
ord-e55c2f12d91d4fbfafb097eb068245c2
Source dataset
uspto-grants-1998_02
Patent number
US05721347

Reaction notes

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