Hydrochloric Acid → HCID 20373228, compound

Participants

Reaction Steps

A solution of 1.4 g. (0.004 mole) of 5-(ρ-chlorobenzoyl)-4-methyl-2-carboxypyrrole-3-acetic acid in 25 ml. quinoline is heated overnight at 160° C. under nitrogen. The reaction is poured into ice acidified with hydrochloric acid. The mixture is extracted with chloroform, and the organic phase is extracted with a saturated solution of sodium bicarbonate. The basic solution is made acidic with dilute hydrochloric acid, and the resulting solid, 5-(ρ-chlorobenzoyl)-4-methylpyrrole-3-acetic acid, is filtered and purified by recrystallization from isopropyl alcohol, M.P. 145°-147° C.

Provenance & Evidence