Hydrochloric Acid → HCID 18424284, compound

Participants

Reaction Steps

A suspension of 18.2 g. (0.044 mole) of ethyl 5-(ρ-chlorobenzoyl)-3-ethoxycarbonyl-4-ethyl-1-methylpyrrole-2-acetate in 170 ml. of 25% aquous sodium, hydroxide solution is heated under reflux for 3 hrs. It is cooled, diluted with water and acidified with dilute hydrochloric acid. The precipitated solid is collected by filtration and air dried. It is recrystallized from acetone-water to give 3-carboxy-5-(ρ-chlorobenzoyl)-4-ethyl-1-methylpyrrole-2-acetic acid, M.P. 211°-212.5° C.

Provenance & Evidence