tert-Butyldimethylsilyl chloride → HCID 54479352, compound

Participants

Reaction Steps

Such a preferred procedure comprises treating the (3S,4S)-4-acetoxy-3-phenylacetamido-azetidin-2-one (II) with tert-butyldimethyl chlorosilane in the presence of 4-dimethylaminopyridine and, optionally, of pyridine in an organic solvent, isolating the (3S,4S)-4-acetoxy-3-phenylacetamido-1-tert-butyldimethylsilyl-azetidin-2-one (III) thus obtained and treating with an inorganic sulfide to obtain (3S,4S)-4-acetoxy-3-phenylethanethioylamino-1-tert-butyldime thylsilyl-azetidin-2-one (IV) and treating this compound with a base in an organic solvent at a temperature of 70°÷130° C.

Provenance & Evidence