Water → 3-[8-(formamidomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione

Participants

Reaction Steps

A solution of 120 mg of the pyrroledione product of Example 6 in 6 ml of dimethylformamide and 6 ml of 33% aqueous ammonia was heated to 140° C. for 6 hours. The cooled mixture was poured into water and the precipitate was filtered off. The product was purified by chromatography on silica gel with dichloromethane/acetic acid/methanol/water (60:18:2:3). Trituration with ethyl acetate gave 50 mg of 3-[8-(formamidomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 332°-334° C.

Provenance & Evidence