Thiourea → 3-[8-[(amidinothio)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]-indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulfonate

Participants

Reaction Steps

A solution of 100 mg of the pyrroledione product of Example 6 and 75 mg of thiourea in 5 ml of dimethylformamide was heated to 80° C. under a nitrogen atmosphere for 18 hours. The solvent was removed by evaporation and the residue was purified by chromatography on silica gel with dichloromethane/methanol/acetic acid/water (90:18:3:2). The residue was triturated with ethyl acetate to give 80 mg of 3-[8-[(amidinothio)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]-indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulfonate of melting point 200°-205° C.

Provenance & Evidence