Pyridine → HCID 19696325, compound

Participants

Reaction Steps

A solution of 500 mg of the pyrroledione product of Example 13 in 50 ml of dichloromethane was treated with 218 mg of methanesulfonic anhydride and 1 ml of pyridine. The resulting solution was stirred at room temperature under a nitrogen atmosphere for 1 hour. An additional 20 mg of methanesulfonic anhydride were then added and stirring was continued for 0.5 hour. The mixture was washed with water, dried and evaporated. Crystallization of the residue from ethyl acetate/petroleum ether gave 540 mg of 3-[6,7,8,9-tetrahydro-8-(2-methylsulfonyloxyethyl)pyrido-[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 244°-245° C.

Provenance & Evidence