HCID 19696341, compound → HCID 5327739, compound

Participants

Reaction Steps

200 mg of the pyrroledione product of Example 16 in 70 ml of methanol containing 40 mg of 10% Pd/C were shaken under a hydrogen atmosphere at a pressure of 3 atmospheres for 48 hours. The supernatant was decanted and evaporated. The residue was treated with 50 ml of a saturated solution of hydrogen chloride in ethyl acetate and was then purified by chromatography on silica gel with dichloromethane/methanol/acetic acid/water (60:18:2:3). Crystallization from ethyl acetate gave 20 mg of 3-[8-(2-aminoethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 160°-165° C.

Provenance & Evidence