Ammonia → HCID 19696451, compound

Participants

Reaction Steps

A solution of 150 mg of the product of Example 49 and 146 mg of 2,6-lutidine in 15 ml of dichloromethane was added to a solution of 290 mg of trifluoromethanesulfonic anhydride at 0° C. After 3 hours, 25 ml of 33% aqueous ammonia were added and the mixture was stirred for 16 hours. The mixture was extracted with dichloromethane and the combined extracts were dried and concentrated. Chromatography of the residue on silica gel with dichloromethane/methanol/acetic acid/water (90:18:3:2) gave 50 mg of 3-[9-(aminomethyl)-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indol-11-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione acetate of melting point 215° C. (decomposition).

Provenance & Evidence