Trifluoroacetic anhydride → HCID 19696100, compound

Participants

Reaction Steps

991 mg of trifluoroacetic anhydride were added dropwise to a suspension of 1.0 g of 6,7,8,9-tetrahydropyrido[1,2-a]indole-8-carboxamide in 15 ml of dioxane at 10° C. The mixture was partitioned between dichloromethane and water and the organic phase was dried. The solvent was removed under reduced pressure to give an oil which was subjected to chromatography on silica gel with ethyl acetate/petroleum ether (1:1). There were obtained 740 mg of 6,7,8,9-tetrahydropyrido[1,2-a]indole-8-carbonitrile of melting point 116°-118° C.

Provenance & Evidence