Triethylamine → HCID 19696317, compound

Participants

Reaction Steps

A solution of 150 mg of the product of Example 20 in 40 ml of dichloromethane was treated with 40 mg of triethylamine and 44 mg of methanesulfonyl chloride. After 17 hours, the solution was washed with water. The organic phase was dried and evaporated. Chromatography of the residue on silica gel with ethyl acetate/n-hexane (2:1) and ethyl acetate gave 95 mg of 3-[1,2,3,4-tetrahydro-2-methanesulfonylpyrazino[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 298°-301° C. (decomposition).

Provenance & Evidence