Dichloromethane → HCID 19696421, compound

Participants

Reaction Steps

2.2 g of oxalyl chloride were added to an ice-cold solution of 4 g of 8-(acetoxymethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indole in 50 ml of dichloromethane. After 2 hours, the solvent was evaporated and the residue was dissolved in dichloromethane. This solution was added to a solution of 3.0 g of 2-chlorophenylacetic acid and 4.0 g of triethylamine in dichloromethane. The mixture was stirred for 16 hours and then concentrated. Chromatography of the residue on silica gel with dichloromethane/methanol (95:5) yielded 0.9 g of 3-[8-(acetoxymethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(2-chlorophenyl)furan-2,5-dione of melting point 168°-171° C.

Provenance & Evidence