Methyl isothiocyanate → HCID 86749875, compound

HRID 863732Notes

Reaction equation

HRID 863732 reaction equation
[C:1]([NH:8][NH:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)([C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:2].[CH3:17][N:18]=[C:19]=[S:20]>C(O)C>[C:1]([NH:8][NH:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][C:19]([NH:18][CH3:17])=[S:20])=[CH:14][CH:15]=1)([C:3]([O:5][CH2:6][CH3:7])=[O:4])=[O:2]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 15919696HCID 15919696, compound

Product 1

HCID 86749875HCID 86749875, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.9 g of 1-ethoxalyl-2-(4-aminophenyl)hydrazine and 3.0 g of methyl isothiocyanate were added to 75 ml of ethanol, followed by refluxing for 3.5 hours under heating. The refluxed product was left to stand for cooling and the precipitated crystal was collected by filtration, washed with ethanol and then dried to obtain 8.6 g of 1-ethoxalyl-2-[4-(3-methylthioureido)phenyl]hydrazine (intermediate A) having a melting point of 168°-169° C.

Workup

  1. temperatureby refluxing for 3.5 hours
  2. temperatureunder heating
  3. waitThe refluxed product was left
  4. temperaturefor cooling
  5. filtrationthe precipitated crystal was collected by filtration
  6. washwashed with ethanol
  7. customdried

Sources & evidence

ORD record
ord-77615142d29b477489e62f3cf83bdbff
Source dataset
uspto-grants-1996_10
Patent number
US05561028

Reaction notes

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