Hydrochloric Acid → HCID 15300825, compound

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Reaction Steps

0.208 g of 50% NaOH is added at 55° to a solution of 0.551 g of 5-chloro-5-(4,6-dimethoxy-2-pyrimidinyl)-furo[3,4,b]pyridine (Table B, cpd. no. 68) in 50 ml methanol. The mixture stirred for a further 1/2 hr at 55°, cooled in an ice-bath, acidified with 1 ml of concentrated HCl and the solvent evaporated. The residue is partitioned between 50 ml of CH2Cl2 and 50 ml H2O and the CH2Cl2 layer concentrated to give 0.39 g of the title product as a white solid, m.p. 71°-73° C.

Provenance & Evidence