Methanol → HCID 19050666, compound

HRID 863753Notes

Reaction equation

HRID 863753 reaction equation
[CH3:1][C:2]1([CH3:22])[CH2:6][O:5][C:4]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][C:10]2[N:15]=[C:14](Cl)[CH:13]=[C:12](Cl)[N:11]=2)=[N:3]1.[O:23]([CH3:25])[Na].[CH3:26][OH:27]>C1(C)C=CC=CC=1.O>[CH3:1][C:2]1([CH3:22])[CH2:6][O:5][C:4]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][C:10]2[N:15]=[C:14]([O:27][CH3:26])[CH:13]=[C:12]([O:23][CH3:25])[N:11]=2)=[N:3]1

Participants

6

Reactant 3

HCID 887MethanolHCID 190506632(2-(4,4-Dimethyl-oxazolin-2-yl)-benzyl)-4,6-dichloropyrimidineHCID 178418582HCID 178418582, compound

Product 1

HCID 19050666HCID 19050666, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1140TolueneSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of 1.7 g of 2(2-(4,4-dimethyl-oxazolin-2-yl)-benzyl)-4,6-dichloropyrimidine in 100 ml of methanol are added 2.18 g of 25% methanolic NaOCH3 and the mixture heated for 10 hrs at 65° C. with stirring. The temperature is lowered to 60° and stirring continued overnight. The solvent is stripped and the residue taken up in 80 ml of toluene and 50 ml of water. The toluene layer was separated and washed with 50 ml of water, separated and concentrated to give the title compound as a yellow oil.

Workup

  1. customis lowered to 60°
  2. stirringstirring continued overnight
  3. customThe toluene layer was separated
  4. washwashed with 50 ml of water
  5. customseparated
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-331ad1804e6741d9ace02794cf1cbcf9
Source dataset
uspto-grants-1996_10
Patent number
US05561101

Reaction notes

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