HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 863762Generated: October 31, 2026
Thionyl Chloride → 5-Chloro-5-(4,6-dimethoxy-2-pyrimidinyl)furo[3,4-b]pyridin-7(5H)-one
https://huagongshe.com/reaction/863762
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 15300825 | HCID 15300825 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 5-Chloro-5-(4,6-dimethoxy-2-pyrimidinyl)furo[3,4-b]pyridin-7(5H)-one | HCID 19050641 | — |
Reaction Steps
45.53 g of 3-[(4,6-dimethoxy-2-pyrimidinyl)carbonyl]-2-pyridinecarboxylic acid are suspended in 700 ml of carbon tetrachloride and 186.4 g of thionyl chloride added with stirring. The suspension is heated to 70° C. for 4 hrs and the reaction mixture then cooled to RT and the excess thionyl chloride and carbon tetrachloride evaporated off to give the title compound as a tan solid m.p. 146°-148° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05561101 |
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| Source dataset | uspto-grants-1996_10 |
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| ORD ID | ord-6323326f8c8d463085a4014cdd0b22a7 |
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| Source note | uspto-grants-1996_10 |
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