Dicyclohexylcarbodiimide → HCID 70050906, compound

Participants

Reaction Steps

After hydrogenation of 2.2 g of the product from stage C) of example 6 analogously to stage C) of example 4, the product is further reacted with 1.34 g of N-Boc-p-amidinobenzoic acid (preparation analogously to N-Boc-p-amidinophenylacetic acid), 0.7 ml of triethylamine, 0.852 g of HOBT and 1.04 g of DCC, as in stage C) of example 4, and subsequently deprotected with 25 ml of TFA/anisole (95/5), and worked up, to produce the (S)-3-[N-(3-methylbutyryl)amino]-7-[N-(p-amidinobenzoyl)amino]heptanoic acid trifluoroacetate product in the form of a white powder; MS: 391 (M+H)+. The free compound is produced from the trifluoroacetate in known manner.

Provenance & Evidence