反应详情

温度

80 °C

N-trityl-2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine (9.1 g; 17.8 mmol) is suspended in EtOH and treated with HCl/EtOH until acidic by pH paper. The reaction mixture is heated at 80° C. for 3 hours keeping the reaction acidic. The reaction mixture is then cooled and the solid is filtered and washed with EtOH to give 2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine hydrochloride (m.p. 232°-233° C.) as a white solid which is used directly in Step F.

1. temperatureThe reaction mixture is then cooled
2. filtrationthe solid is filtered
3. washwashed with EtOH