HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-[4-(Benzoxazol-2-yl)benzyloxy]-3-(4-phenylbutoxy)-2-propanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | N-trityl-1-[4-(benzoxazol-2-yl)benzyloxy]-3-(4-phenylbutoxy)-2-propanamine | HCID 19420792 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[4-(Benzoxazol-2-yl)benzyloxy]-3-(4-phenylbutoxy)-2-propanamine hydrochloride | HCID 19420736 | — |
Reaction Steps
N-trityl-1-[4-(benzoxazol-2-yl)benzyloxy]-3-(4-phenylbutoxy)-2-propanamine (0.3 g; 0.45 mmol) is dissolved in CH2Cl2 (3 ml) and MeOH (3 ml) and acidified to pH3 with acidic methanol. The reaction is stirred 1.5 hours, concentrated and purified by column chromatography with 8% MeOH/CH2Cl2. The product is isolated, dissolved in MeOH and acidified with acidic methanol. The solution is concentrated to yield 1-[4-(benzoxazol-2-yl)benzyloxy]-3-(4-phenylbutoxy)-2-propanamine hydrochloride (m.p. 125°-126° C. ).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05561143 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-fee7da58c65246fd9d561e80a7d3ea42 |
| Source note | uspto-grants-1996_10 |