Acetonitrile → HCID 86749626, compound

Participants

Reaction Steps

A mixture of N-(diphenylmethylene)glycine ethyl ester (6.85 g; 25.6 mmol), 4-(benzoxazol-2-yl)benzyl bromide (7.37 g; 25.6 mmol), tetrabutylammonium bromide (0.83 g; 2.6 mmol); potassium carbonate (10.6 g; 77 mmol) and dry acetonitrile (50 ml) is heated at reflux 4 hours. The reaction is cooled and diluted with CH2Cl2, washed with water, dried (Na2SO4) and concentrated in vacuo to yield ethyl 2-[4-(benzoxazol-2yl)benzyl]-N-(diphenylmethylene)glycine as an oil which is used directly without further purification in Step B.

Provenance & Evidence