Sodium Hydroxide → HCID 14595976, compound

Participants

Reaction Steps

Treat CIS-2,3-dihydro-1-(4-trifluoromethylphenoxy)-N-benzyl-N-methyl-1H-indene-2-methanamine hydrochloride with a sodium hydroxide solution to obtain the oily base CIS-2,3-dihydro-1-(4-trifluoromethylphenoxy)-N-benzyl-N-methyl-1H-indene-2-methanamine. Dissolve CIS-2,3-dihydro-1-(4-trifluoromethylphenoxy)-N-benzyl-N-methyl-1H-indene-2methanamine (11.9 g, 0.029M) in 150 ml of methylene chloride and to this solution add potassium carbonate (5 g). Add phenylchloroformate (5.4 g, 0.034M) dropwise and stir the mixture for 3 hours. Sequentially shake the mixture with water, dilute hydrochloric acid and then water. Dry the organic layer over magnesium sulfate. Remove the solvent and recrystallize the residue from cyclohexane to yield 8.9 g (69% yield) of the title compound [melting point =101°-102° C⟧

Provenance & Evidence