6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → 2-[6-(3,4-Dimethoxyphenyl)-6-[(4-methylphenyl)thio]hexyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Participants

Reaction Steps

The procedure of Example 39 is repeated using 2.12 g of 4-[6-Bromo-1-[(4-methylphenyl)thio]hexyl]-1,2-dimethoxybenzene and 2.3 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 1.6 g of the desired product as a light yellow oil. MS(Hi res): m/z Calcd for C32H41NO4S 535.2756 Found 536.2834(M+H). Calcd for C32H41NO4S: C=70.13, H=7.83, N=3.07, S=5.62 Found C=70.15, H=7.51, N=2.79, S=5.25

Provenance & Evidence