5,6,7,8-Tetrahydro-1,3-dioxolo(4,5-g)isoquinoline → 6-[6-(3,4-Dimethoxyphenyl)-6-[(4-methylphenyl)thio]-hexyl]-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline

Participants

Reaction Steps

The procedure of Example 46 is repeated using 3.67 g of 4-[6-bromo-1-[(4-methylphenyl)thio]hexyl]-1,2-dimethoxybenzene in 40 mL of acetonitrile and 2.65 g of 6,7-methylenedioxy-1,2,3,4-tetrahydroiso quinoline. This affords 4.13 g of the desired product as a yellow gum. MS(CI): m/z 520(M+H+). Calcd for C31H37NO4S 7/8H2O: C=69.53, H=7.15, N=2.57, S=5.84 Found C=69.54, H=7.30, N=2.62, S=5.98

Provenance & Evidence