Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1) → alpha-(3,4-Dimethoxyphenyl)-1-[(3,4-dimethoxyphenyl) methyl]-3,4-dihydro-6,7-dimethoxy-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile

Participants

Role	Name	HCID	Charge
Reactant	Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)	HCID 16667431	—
Reactant	alpha-(5-Iodopentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrile	HCID 19042083	—
Product	alpha-(3,4-Dimethoxyphenyl)-1-[(3,4-dimethoxyphenyl) methyl]-3,4-dihydro-6,7-dimethoxy-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile	HCID 19042104	61.1%

Reaction Steps

The procedure of Example 49 is repeated using 0.345 g of tetrahydropapaverine hydrochloride and 0.30 g of α-(5-iodopentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile. This affords 0.263 g of the desired product as a yellow oil. MS(Hi res): m/z Calcd for C42H50N2SO6 711.34678 Found 711.3453

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05561141
Source dataset	uspto-grants-1996_10
ORD ID	ord-e5b448cf6527458a8d70eb4b80b58fc1
Source note	uspto-grants-1996_10