Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) → 5-(2-Chloroethoxy)-alpha-(3,4-dimethoxyphenyl)-1,3-dihydro-6-methoxy-alpha-[[4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile

Participants

Reaction Steps

The procedure of Example of 32 is used with 0.45 g of α-(3,4-dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile and 0.65 g of 2-chloroethyl p-toluenesulfonate. This affords 0.367 g of the desired product as a light brown oil. MS(Hi res): m/z Calcd for C33H39N2SClO4 595.2397 Found 595.2391(M+H)

Provenance & Evidence