Fumaric Acid → HCID 19420960, compound

Participants

Reaction Steps

1.1 g (3.88 mmol) of (RS)-1-(2-azido-propyl)-7-methoxy-3-methyl-1,4-dihydro-indeno[2,1-c]pyrazole dissolved in 60 ml of anhydrous ethanol were hydrogenated over 110 mg of platinum oxide for 2 hours. The catalyst was subsequently filtered off, rinsed with ethanol and the solvent was removed in a vacuum. The colorless oil obtained was dissolved in 120 ml of anhydrous diethyl ether, filtered and treated while stirring with a solution of 450 mg (3.88 mmol) of fumaric acid in 5 ml of methanol. The mixture was stirred at room temperature for 15 hours and the white crystals were subsequently filtered off. 1.2 g (83%) of (RS)-2-(7-methoxy-4-methyl-1,4-dihydroindeno[2,1-c]pyrazol-1-yl)-1-methyl-ethylamine fumarate (1:1) with m.p. 184° were obtained.

Provenance & Evidence