Diazomethane → HCID 19420935, compound

Participants

Reaction Steps

A solution of 0.79 g (18.8 mmol) of diazomethane in 56 ml of anhydrous diethyl ether was added while stirring to a solution of 2.44 g (9.37 mmol) of (RS)-1-(7-methoxy-1,4-dihydro-indeno[2,1-c]pyrazol-3-on-1-yl)-propan-2-ol in 80 ml of anhydrous diethyl ether and 50 ml of anhydrous methanol. The mixture was stirred at room temperature for a further 15 hours and subsequently concentrated in a vacuum. 2.08 g (81%) of (RS)-1-(3,7-dimethoxy-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl)-propan-2-ol were obtained as a brown solid which was used directly in the next reaction.

Provenance & Evidence