Cysteamine Hydrochloride → HCID 131718855, compound

HRID 864083Notes

Reaction equation

HRID 864083 reaction equation
[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4]([Cl:6])=[O:5].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>CCOCC>[ClH:6].[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](=[O:5])[S:14][CH2:13][CH2:12][NH2:11]

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

Product 1

HCID 131718855HCID 131718855, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 3,4,4-trifluoro-3-butenoyl chloride (2.5 g, 0.0158 mole) and 2-aminoethanethiol hydrochloride (1.14 g, 0.010 mole) is slowly heated to reflux for 15 min. The mixture is cooled to room temperature and treated with dry ether and filtered. The product is recrystallized from absolute ethanol to give 0.8 g of the title compound as a off-white solid, a 34% yield. m.p. 95°-115° C.

Workup

  1. temperatureis slowly heated
  2. temperatureto reflux for 15 min
  3. filtrationfiltered
  4. customThe product is recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-f06e305f991b448399fea331e0aaa0b4
Source dataset
uspto-grants-1996_10
Patent number
US05561162

Reaction notes

Loading…