O-methylhydroxylammonium chloride → HCID 67768684, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of Example 3 Part D aminonitrile (0.34 g, 0.74 mmol) in 3.0 mL of 1-methyl-2-pyrrolidinone was added methoxyamine.HCl (0.18 g, 216 mmol). This reaction solution was immersed into a 85° C. oil bath. The bath temperature was slowly raised up no 130° C. in 80 min. The reaction solution was stirred at 130° C. for 2 h and cooled to room temperature. The solution was diluted with 30 mL of ether and the solution was decanted. The remaining oily residue was purified by preparative HPLC to give 250 mg (51%) of title compound.

Provenance & Evidence