2-Chloro-6-fluoropyrazine → HCID 178444296, compound

HRID 864268Notes

Reaction equation

HRID 864268 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([F:8])[N:3]=1.[CH2:9]([C@H:14]1[CH2:19][CH2:18][C@H:17]([C:20]2[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)[CH2:10][CH2:11][CH2:12][CH3:13]>>[F:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([C:23]2[CH:22]=[CH:21][C:20]([C@H:17]3[CH2:18][CH2:19][C@H:14]([CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:15][CH2:16]3)=[CH:25][CH:24]=2)[N:3]=1

Participants

3

Reactant 2

HCID 232733782-Chloro-6-fluoropyrazineHCID 178444242HCID 178444242, compound

Product 1

HCID 178444296HCID 178444296, compoundYield 62.7%

Procedure

In an analogous reaction to Example 1b, 2.17 g (16.41 mmol) of 2-chloro-6-fluoropyrazine (prepared as described in Example 1a) and 4.50 g (16.41 mmol) of 4-(trans-4-pentylcyclohexyl)phenylboronic acid gives 3.36 g of 2-fluoro-6-[4-(trans-4-pentylcyclohexyl)-phenyl]pyrazine. ##STR19## 3b

Sources & evidence

ORD record
ord-334b7609959f4e86a0e141f18f485a53
Source dataset
uspto-grants-1996_10
Patent number
US05562859

Reaction notes

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