HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Tert-butyldiphenylsilyloxybenzeneboronic acid → 2-Fluoro-6-(4-tert-butyldiphenylsilyloxyphenyl)pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Tert-butyldiphenylsilyloxybenzeneboronic acid | HCID 21807291 | — |
| Reactant | 2-Chloro-6-fluoropyrazine | HCID 23273378 | — |
| Product | 2-Fluoro-6-(4-tert-butyldiphenylsilyloxyphenyl)pyrazine | HCID 54233195 | 69.5% |
Reaction Steps
In an analogous reaction to Example 1b, 8.86 g (66.85 mmol) of 2-chloro-6-fluoropyrazine (prepared as described in Example 1a) and 25.13 g (66.85 mmol) of 4-tert-butyldiphenylsilyloxyphenylboronic acid give 19.90 g of 2-fluoro-6-(4-tert-butyldiphenylsilyloxyphenyl)pyrazine. ##STR22## 4b
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05562859 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-bd6d16e92ad24c619ea47c272d2fe16f |
| Source note | uspto-grants-1996_10 |