HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 178418304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate | HCID 54242925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178418304 | HCID 178418304 | — |
Reaction Steps
Ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (3.5 g) is dissolved in ethanol (25 ml) and thereto cyclopropylamine (0.84 ml) is added dropwise under ice-cooling. After stirring at room temperature for 30 minutes, the mixture is concentrated and the residue is purified with column chromatography (silica-gel, dichloromethane: n-hexane=1:1) to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-cyclopropylaminoacrylate (2.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05563138 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-c6b35e459f08445382da640eb5a53242 |
| Source note | uspto-grants-1996_10 |