HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 864351Generated: October 25, 2026
4-Piperidone → 1-Cyclopropyl-6-fluoro-7-(4-oxo-1-piperidinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
https://huagongshe.com/reaction/864351
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Piperidone | HCID 33721 | — |
| Reactant | 7-Bromo-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 10132015 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-Cyclopropyl-6-fluoro-7-(4-oxo-1-piperidinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 18974502 | 37.6% |
Reaction Steps
To a solution of 1-cyclopropyl-6-fluoro-7-bromo-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.58 g) in N-methyl-2-pyrrolidone (5 ml) is added 4-oxopiperidine (0.64 g) and the mixture is heated at 90° C. for 20 minutes. The solvent is distilled off under reduced pressure. To the resulting residue is added ethanol and the precipitated crystals are filtered to give 1-cyclopropyl-6-fluoro-7-(4-oxo-1-piperidinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (230 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05563138 |
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| Source dataset | uspto-grants-1996_10 |
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| ORD ID | ord-86bfb7fab5b64e22a7a3c7d8c9cbbdd0 |
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| Source note | uspto-grants-1996_10 |
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