Ethylene Glycol → HCID 19418834, compound

Participants

Reaction Steps

Sodium hydride in oil (60%, 131 mg) is added to ethylene glycol (6.0 ml) and 2-chloro-3-nitropyridine (430 mg) is added. The mixture is stirred for 26 hours during which time additional sodium hydride in oil (60%, 100 mg) is added. Water is added, the pH is adjusted to 9 and the solution is extracted with methylene chloride (3×50 ml). The combined organic layers are dried with saline and sodium sulfate and concentrated. Chromatography on silica gel with a methanol/chloroform gradient affords the title compound, Rf =0.32 (TLC on silica gel, ethyl acetate/hexane [50/50]).

Provenance & Evidence