Potassium Hydroxide → HCID 19418871, compound

HRID 864416Notes

Reaction equation

HRID 864416 reaction equation
[Br:1][C:2]1[C:3]([O:15][CH3:16])=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([O:13]C)=[O:12])=[CH:7]2.[OH-].[K+]>>[Br:1][C:2]1[C:3]([O:15][CH3:16])=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([OH:13])=[O:12])=[CH:7]2

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 16726759Methyl 7-bromo-6-methoxy-1H-indole-2-carboxylate

Product 1

HCID 19418871HCID 19418871, compound

Procedure

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 7-bromo-6-methoxyindole carboxylate (PREPARATION 81, 0.36 g) and potassium hydroxide (0.11 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.58, 7.20, 6.96 and 3.93 δ.

Workup

  1. customthe general procedure of PREPARATION 63

Sources & evidence

ORD record
ord-278a6ce31b3c47f389071bfab420b31d
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

Loading…