Potassium Hydroxide → 4-Methyl-1H-indole-2-carboxylic acid

HRID 864418Notes

Reaction equation

HRID 864418 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([O:13]C)=[O:12])[NH:6]2.[OH-].[K+]>>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([OH:13])=[O:12])[NH:6]2

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 4714967methyl 4-methyl-1H-indole-2-carboxylate

Product 1

HCID 39260874-Methyl-1H-indole-2-carboxylic acid

Procedure

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 4-methylindole-2-carboxylate (PREPARATION 85, 4.94 g), potassium hydroxide (1.75 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.24, 7.19, 7.12, 6.85 and 2.51 δ.

Workup

  1. customthe general procedure of PREPARATION 63

Sources & evidence

ORD record
ord-678094f839db46c48dd88f1fc8fe470e
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

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