HCID 21477603, compound → HCID 10446014, compound

HRID 864423Notes

Reaction equation

HRID 864423 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([NH:23][C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[F:27][C:25]([F:26])([F:28])[C:24]([NH:23][C:22]1[C:17]([N:14]2[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]2)=[N:18][CH:19]=[CH:20][CH:21]=1)=[O:29]

Participants

4

Reactant 1

HCID 21477603HCID 21477603, compound

Product 1

HCID 10446014HCID 10446014, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-[Benzyloxycarbonyl]-4-[3-(2,2,2-trifluoroacetamido)-2-pyridinyl]piperazine (PREPARATION 101), is dissolved in 70 ml of ethanol and 0.25 g of 10% palladium on carbon is added. The reaction is hydrogenated at 40 psi for 20 hr. Then it is filtered through a pad of celite and concentrated in vacuo to afford the title compound which is used without further purification, NMR (300 MHz, CDCl3) 8.51, 8.21, 7.19, and 3.45-3.47 δ.

Workup

  1. filtrationThen it is filtered through a pad of celite
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-d78a7438945945e9b50752f405bcdcde
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

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