5-Fluoroindole-2-carboxylic acid → HCID 489432, compound

HRID 864437Notes

Reaction equation

HRID 864437 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=O)=[CH:5]2.[CH3:14][C:15]([NH:18][CH:19]1[NH:24][CH2:23][CH2:22][NH:21][CH:20]1C1C=NC=CN=1)([CH3:17])[CH3:16]>>[CH3:17][C:15]([NH:18][C:19]1[C:20]([N:21]2[CH2:22][CH2:23][N:24]([C:11]([C:6]3[NH:7][C:8]4[CH:9]=[CH:10][C:2]([F:1])=[CH:3][C:4]=4[CH:5]=3)=[O:13])[CH2:19][CH2:20]2)=[N:21][CH:22]=[CH:23][N:24]=1)([CH3:14])[CH3:16]

Participants

3

Reactant 2

HCID 18205-Fluoroindole-2-carboxylic acidHCID 57132795HCID 57132795, compound

Product 1

HCID 489432HCID 489432, compound

Procedure

Following the general procedure of EXAMPLE 16 and making non-critical variations but starting with 5-fluoroindole-2-carboxylic acid (0.44 g) and 3-(1,1-dimethylethylamino)-2-pyrazinylpiperazine (2.50 mmol), a solid is obtained which is recrystallized from ethyl acetate to give the title compound.

Workup

  1. customa solid is obtained which
  2. customis recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-0ae325533a9b46edb0c07c93a07f06a4
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

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