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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 864441Generated: October 30, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1H-indole, 2-[[4-[3-(1-pyrrolidinyl)-2-pyridinyl]-1-piperazinyl]carbonyl]-

https://huagongshe.com/reaction/864441

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
ReactantIndole-2-carboxylic acidHCID 72899—
Reactant1-[3-(1-Pyrrolidinyl)-2-pyridinyl]piperazineHCID 21477630—
Product1H-indole, 2-[[4-[3-(1-pyrrolidinyl)-2-pyridinyl]-1-piperazinyl]carbonyl]-HCID 489444—

Reaction Steps

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with indole-2-carboxylic acid (0.12 g), 1-[3-(1-pyrrolidinyl)-2pyridinyl]piperazine (PREPARATION 48, 0.17 g) and 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.17 g), the title compound is obtained, mp 181°-182°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05563142
Source datasetuspto-grants-1996_10
ORD IDord-b40d1415457d40f2872e8ddc2cf35d98
Source noteuspto-grants-1996_10