1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-(3,5-Dimethyl-4-methoxybenzoyl)-4-[3-[(1-methylethyl)amino]-2-pyridinyl]piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
Reactant	3,5-Dimethyl-p-anisic acid	HCID 88944	—
Reactant	3-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)-	HCID 10013750	—
Product	1-(3,5-Dimethyl-4-methoxybenzoyl)-4-[3-[(1-methylethyl)amino]-2-pyridinyl]piperazine	HCID 455376	—

Reaction Steps

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 3,5-dimethyl-4-methoxybenzoic acid (0.075 g), 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (0.101 g) and 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.096 g), the title compound is obtained, mp 89°-93°.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05563142
Source dataset	uspto-grants-1996_10
ORD ID	ord-2c5bb053cfbe4216b12027782d10462b
Source note	uspto-grants-1996_10