1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-[5-Fluoro-6-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
Reactant	3-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)-	HCID 10013750	—
Reactant	5-Fluoro-6-methoxy-1h-indole-2-carboxylic acid	HCID 19418795	—
Product	1-[5-Fluoro-6-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine	HCID 489450	—

Reaction Steps

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 5-fluoro-6-methoxyindole-2-carboxylic acid (PREPARATION 92, 0.30 g), 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (0.32 g) and 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.33 g), the title compound is obtained, mp 193°-194°.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05563142
Source dataset	uspto-grants-1996_10
ORD ID	ord-c97ffbbbf50b4036935bfa5e9be54162
Source note	uspto-grants-1996_10