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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 864445Generated: November 2, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-[5-Bromo-6-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine

https://huagongshe.com/reaction/864445

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
Reactant3-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)-HCID 10013750—
Reactant5-bromo-6-methoxy-1H-indole-2-carboxylic acidHCID 19418869—
Product1-[5-Bromo-6-methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazineHCID 489453—

Reaction Steps

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 5-bromo-6-methoxyindole-2-carboxylic acid (PREPARATION 82, 0.40 g), 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (0.33 g) and 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.34 g), the title compound is obtained, mp 202°-204°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05563142
Source datasetuspto-grants-1996_10
ORD IDord-65e884d3e109404b9ed38f08e9980581
Source noteuspto-grants-1996_10