HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-[5-Nitroindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 5-Nitroindole-2-carboxylic acid | HCID 351291 | — |
| Reactant | 3-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)- | HCID 10013750 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[5-Nitroindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine | HCID 489456 | — |
Reaction Steps
Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 5-nitroindole-2 -carboxylic acid (0.86 g), 1-[3-(N-isopropyl)amino-2-pyridinyl]piperazine (0.43 g), 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.45 g) and THF (4 ml), the title compound is obtained, mp 153°-154°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05563142 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-fa828255da2d44998d921e20a02e9dfb |
| Source note | uspto-grants-1996_10 |