3H-Benzo[e]indole-2-carboxylic acid → HCID 489468, compound

HRID 864449Notes

Reaction equation

HRID 864449 reaction equation
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[CH:6]=[CH:5][C:4]=2[NH:3][C:2]=1[C:14]([OH:16])=O.[CH3:17][CH:18]([NH:20][C:21]1[C:22]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:23][CH:24]=[CH:25][CH:26]=1)[CH3:19]>>[CH3:19][CH:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[N:23][C:22]=1[N:27]1[CH2:28][CH2:29][N:30]([C:14]([C:2]2[NH:3][C:4]3[CH:5]=[CH:6][C:7]4[C:8]([C:9]=3[CH:1]=2)=[CH:10][CH:11]=[CH:12][CH:13]=4)=[O:16])[CH2:31][CH2:32]1)[CH3:17]

Participants

3

Reactant 2

HCID 3549663H-Benzo[e]indole-2-carboxylic acidHCID 100137503-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)-

Product 1

HCID 489468HCID 489468, compound

Procedure

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with benz[e]indole-2-carboxylic acid (PREPARATION 116, 0.5 g) and 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (PREPARATION 8, 0.52 g), the title compound is obtained, m.p. 228°-231°.

Sources & evidence

ORD record
ord-1aa9634b92d547a1828037ae8f0974d8
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

Loading…