Potassium Hydroxide → HCID 22866402, compound

Participants

Reaction Steps

2M Potassium hydroxide (2.5 ml) was added to a solution of N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-1-yl)hexanoyl-L-leucine ethyl ester (200 mg, 0.50 mmol) in ethanol (70 ml). The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure and water was added to the residue. The pH of the resulting solution was adjusted to pH 6 by the addition of 2M HCl, the mixture was saturated with sodium chloride and extracted with DCM. The combined organic extracts were dried over anhydrous sodium sulphate, filtered and evaporated to give N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-1-yl)hexanoyl-L-leucine (70 mg, 38%) as a white foam.

Provenance & Evidence