HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → Methyl 5-methylthiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | 4-Bromo-2-methylthiophene | HCID 638584 | — |
| Product | Methyl 5-methylthiophene-3-carboxylate | HCID 4644182 | — |
Reaction Steps
Alternatively, initial lithiation of 3-bromo-5-methylthiophene followed by capture with methyl chloroformate gives methyl 5-methylthiophene-3-carboxylate. Free-radical bromination of the methyl group provides 5-(bromomethyl)thiophene-3-carboxylic acid. ##STR46##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05563158 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-555c32ff7e104301aea6374995d0faf5 |
| Source note | uspto-grants-1996_10 |