Piperidin-4-ol → Tert-butyl 4-hydroxypiperidine-1-carboxylate

Participants

Reaction Steps

A solution of 4-hydroxypiperidine (5.05 g; 0.05 mole) in 100 ml of tetrahydrofuran was stirred and cooled in an ice-water bath. Di-tert.butylcarbonate (10.9 g; 0.05 mole) was added and stirring was continued at room temperature for 3 hrs. The solvent was removed under reduced pressure. An oily residue was triturated with petroleum ether. Recrystallization from petroleum ether yielded 9.21 g (92%). Rf (silica gel)=0.42 (ethyl acetate/n-hexane 1:

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